Abstract
This study discusses the development of integrated science interactive multimedia with the theme of energy in life which is integrated with 21st century learning using a guided inquiry model for grade VII students in junior high schools (SMP). Interactive multimedia developed is multimedia that has valid, practice and effective criteria. To get an interactive multimedia that is valid, practice and effective, expert and practitioner reviews are carried out using an instrument in the form of a questionnaire given to experts, practitioners, students and conducting field tests in large groups. The results of the assessment of the validity, practicality and effectiveness of Integrated Science interactive multimedia show that the developed multimedia is in the valid, practical and effective category. It can be concluded that the development of integrated science interactive multimedia based on guided inquiry with the theme of energy in the integrated life of 21st century learning is valid, practical and effective for use in the learning process.