Abstract
The 21st century is the era of rapid knowledge, technology and talent development. Teaching materials are needed to increase these skills to support student learning. The research objective was to determine the effect of inquiry-based science teaching materials on 21st-century skills. The research method used was a meta-analysis of 32 articles in national and international journals. The results of the study obtained by varying the level of education, subjects, teaching materials used, and components of the 21st-century skills of the students stated that the use of inquiry model-based science teaching materials significantly influenced students' 21st-century skills. This meta-analysis research concludes that inquiry-based and educationally diverse science teaching materials significantly impacted students, impacted by science showing materials in light of request models with various, impacted by science guidance materials that utilise various showing strategies and depend on request models. The last skill components have a significant impact on students' 21st-century.