Uji Bioaktivitas Ekstrak Etil Asetat Kulit Manggis (Garcinia mangostana L.) sebagai Antidiabetes pada Mencit Putih (Mus musculus L.) Jantan

Abstract

Diabetes mellitus represents a disease marked with blood glucose level that exceeding situation of normal boundary ( hiperglikemia). Treatment of this disease can be done with medicall and alternativety. Medication of alternativety by using materials of flora owning effect of hipoglikemia like ethyl acetate extract of mangosteen rind (Garcinia mangostana L.). This study about activity determination of antidiabetes ethyl acetate extract of mangosteen rind. This study to know influence giving of ethyl acetate extract mangosteen rind to degradation of blood glucose level of the white male mice (Mus musculus L.), and to determine effective treatment time and dose to blood glucose level of the white male mice. Glucose blood levels determined with glucose tolerance method use appliance of NESCO Multicheck Glucose®. Dose variation ethyl acetate extract of mangosteen rind the used 125, 250 and 500 mg/kg BW with time variation of 60, 90, 120, and 150 minutes. The decreasing blood glucose of analysed statistically by using analysis of variant (ANOVA) and followed by Duncan’s multiple reng test. The decreasing result of examination of KGD (blood glucose level) with dose 125, 250 and 500 mg/kg BW give effect of blood glucose levels  meaning, where calculated F value > critical F value. Price of calculated F value is 6,25, while critical F value is 4,77 (0,01 α). Dose of ethyl acetate extract mangosteen rind that gives the highest blood glucose level 20,4 % is 500 mg/kg BW with time a time of ethyl acetate extracts of mangosteen rind 150 minutes.