Uji Bioaktivitas Antidiabetes Ekstrak Etil Asetat dari Kulit Buah Jengkol (Pitecellobium jiringa (Jack) Prain ex King) pada Mencit Putih (Mus musculus L) Jantan

Abstract

Diabetes mellitus is a metabolic disease characterized by blood glucose level that exceed normal limits (hyperglycemia). Treatment of this disease can be done with medicall and herbs. Among the herbal treatment is to use plants such as pandanus pandan wangi, sambiloto, rind mahkota dewa and rind jengkol (Pithecellobium jiringa (Jack) Prain ex King) which has antidiabetic effect. We have done a research of  antidiabetic bioactivity of ethyl acetate extract from the rind jengkol on white male mice. The goal of research to determine the effect of ethyl acetate extract of the rind jengkol in decreasing blood glucose levels of the male  white mice (Mus musculus L.), and to determine the dose and timing of the ethyl acetate extract in  lowing blood glucose level to the olwest point. Research was conducted with on experimental study with a completely randomized design (CRD) with two factor variation is doses of ethyl acetate extract (125, 250, and 500 mg / kg mice) and treatment time (60,90,120, and 150 minutes). This study uses a glucose tolerance test. Blood glucose level of mice were measured using a Glucose Multicheck NESCO ®. Data were statistically analyzed using analysis of variants (ANOVA), followed by Duncan's multiple reng test. The result showed that the ethyl acetate extract of the rind jengkol on white male mice gives the effect on decreasing the mean blood glucose level, which F_calculated> F_table. F_calculated is 10.93, while the F table is 4.77 (0.01 α). Dose of ethyl acetate extract rind jengkol that gives the highest blood glucose level drop is 500 mg / kg with a treatment time of ethyl acetate extract of rind jengkol 150 minutes.