In Silico Senyawa Bioaktif Pada Mulberry (Morus alba L.) dengan Protease HMG-CoA Reduktase Varian 1HW9

Abstract

Cholesterol is a fatty substance that circulates in the blood, is produced by the liver and is needed by the body. High cholesterol can cause cardiovascular disease. This research was conducted to analyze the purification and study of molecular docking of the bioactive compounds contained in Mulberry (Morus alba L.) with the protease HMG CoA reductase variant 1HW9. The method uses the MOE 2009.10 application. The study was carried out by observing the 2D conformation of the molecule and the ligand used. The device used is an Intel(R) Celeron(R) N4000 CPU @ 1.10GHz 1.10 GHz. The HMG CoA reductase protease was retrieved from the protein databank (PDB) website (https://www.rcsb.org/). The bioactive compounds were obtained from Pubchem (www.pubchem.com). The results showed that the value of binding affinity was carried out, several compounds have potential as candidates for anti-cholesterol drugs by inhibiting HMG-CoA reductase.