Studi In Silico Ekstrak Daun Jati Belanda (Guazuma ulmifolia) Kandidat Inhibitor Squalene Synthase

Abstract

Guazuma ulmifolia is a woody plant, has seeds and can reach 30 meters in height. G. ulmifolia leaves has anti-cholesterol properties. In this study, the in silico method was used from extract of G. ulmifolia leaves. The bioactive compounds in the leaves were obtained from the GC-MS process. The bioactive compounds act as ligands to be operated with the SqS enzyme in the MOE 2009.10 software. Squalene synthase plays a role in cholesterol biosynthesis. In addition to the ligands extracted from G.ulmifolia leaves, simvastatin were also used as positive controls. This research aimed to prediction biology activity, drug-likeness analysis and molecular docking of bioactive compound in G.ulmifolia leaves. Bioactive compounds that have potential as anti-cholesterol were obtained from interactions with SqS namely gamma-tocopherol.