In Silico Ekstrak Buah Coccinia grandis L. dalam Penghambatan Enzim α-Glukosidase dan α-Amylase sebagai Antidiabetes

Abstract

Diabetes mellitus is a chronic metabolic disease caused by the cessation of the insulin production process in the organs that play a role in producing insulin and is one of the causes of death in Indonesia. Coccinia grandis L. fruit contains bioactive compounds of flavonoids, alkaloids, glycosides, saponins, steroids, terpenoids, tannins and phenolic compounds which can inhibit enzymes that trigger diabetes mellitus. This study aims to analyze the interaction of compounds from the Coccinia grandis L. plant in inhibiting the enzymes α-glucosidase and α-amylase as an antidiabetic using the protein PDB ID: 5NN8 and PDB ID: 2QV4. The method used in this research is computational through molecular docking using MOE.2009.10 software with the compound acarbose as a drug control in inhibiting the enzymes α-glucosidase and α-amylase. Based on the research results, two compounds with the highest affinity values were obtained, namely dodecanedioic acid and lukianol, which have the potential to inhibit the enzymes α-glucosidase and α-amylase.