UJI IN VIVO EKSTRAK BIJI KAPAS (Gossypium hirsutum L.) TERHADAP KUALITAS PENAMPILAN REPRODUKSI MENCIT (Mus musculus L., Swiss

Abstract

ABSTRACT

Cottonseed used as herbal contraception for male because its containt Gossypol that have antifertility effects. Hormonal control in a male and female are similarly. Gossypol suspected influence to the female reproductive performance. The aim of this experiment is to know the effect of cottonseed exstract to the female mice reproductive performance (Mus musculus L., Swiss Webster). This experiment used Completely Randomized Design with 4 treatments and six-replication. The treatment was namely 0 (kontrol), 0,03 (P1); 0,05 (P2) and 0,07 (P3) gram of cottonseed extract /Kg. B.w. of mice during 18 days. The data of corpus luteum, implantation, life or died fetuses, abnormal and resorbsion fetuses and weight of fetus collected in day 19. The data analyzed by ANOVA and DNMRT (p<0,05). The result showed that cottonseed exstract indicated decreased of corpus luteum, implantation, and life fetuses’ number, and the avarage fetus body weigh. It concludes that cottonseed extract (Gossypium hirsutum L.) decreased the quality of the female mice reproductive performance (Mus musculus L., Swiss Webster).

Keywords: Gossypol, fetus, antifertility, reproductive performance