The Extract of Tristania Sumatrana Miq. to Lower Primary, Secondary and Tertiary Follicles in Swiss Webster Mice

Abstract

The use of traditional medicinal plants is generally based on empirical experience; therefore, a scientific approach is needed to bring traditional medicine into the practice of medicine and formal health services. Tristania sumatrana Miq. is one of the traditional medicinal plants that are often used as contraceptives for women in the villages of Lembah Bawan and Kampung Dalam (West Sumatra). The extract of Tristania sumatrana Miq. can extend the estrus cycle of Mus musculus into eleven days. The purpose of this research is to know the effect of Tristania sumatrana Miq. extract to the fertility of female mice. The experiments were conducted with a randomized 5x2 group design. Five dosage groups: untreated control, placebo, treatment with doses 600, 900 and 1200 mg/kgbw and two treatment groups: 10 and 20 days. The fertility parameters studied were ovarian weight, number of primary, secondary, tertiary follicles. The results prove the extract of Tristania sumatrana Miq. causing a very significant decrease in ovarian weight (treatment of 900 mg/kg bb for 10 days), number of primary and secondary follicles (1200 mg / kg bb for 10 days), and tertiary (600 mg / kg bb for 20 days). The extract of Tristania sumatrana Miq. causing a decline in Mus musculus fertility.