Effect of Mangosteen Skin Extract (Garcinia mangostana L.) on Males Mice (Mus musculus L. Swiss Webster) Uric Acid Level

Abstract

Uric acid (gout) caused by high levels of uric acid in the blood (hyperuricemia). Inflammation caused by uric acid crystals cause pain, stiffness, and swelling in the joints. Gout medication allopurinol commonly consumed ie the mechanism of action as an inhibitor of xanthine oxidase, but this drug side effects such as nausea and diarrhea. The skin of the mangosteen fruit contains xanthones and flavonoids compounds were allegedly able to lower uric acid levels. This study aims to determine the effect of mangosteen peel extract (Garcinia mangostana L.) on uric acid levels in mice (Mus musculus L. Swiss Webster) Males. Research has been conducted in December-January 2016 Biology Laboratory of the Department of Biological Science UNP. This research is experimental method completely randomized design (CRD) ie 4 treatments and 6 replications. Such treatment 0 g / kg (Control / P1), 0.2 g / kg (P2), 0.4 g / kg (P3), 0.6 g / kg (P4). Data were analyzed using ANOVA and using Paired Sample T-Test. Parameters measured were basal uric acid levels before and after treatment. Data taken after 4 days of the treated mice. The results were obtained uric acid levels in mice after treatment are: P1 (Control) 6.43 mg / dL, P2 5.65 mg / dL, P3 3.9 mg / dL, and P4 3.7 mg / dL. Based on the results of this study concluded that the mangosteen rind extract has no effect on uric acid levels in male mice.

Keywords: uric acid (gout), xanthine oxidase, hyperuricemia, an antioxidant.